Our research focuses on the structure-function relationships of the key macromolecules that are involved in various biological processes. Three-dimensional structures of the interested macromolecules have been determined at atomic resolution by a single crystal X-ray diffraction method. Site-directed mutageneses and enzyme kinetics measurements have been used to interpret the structure-function relationships.
Specific research interests:
1. Enzymes in the methyl cycle
2. Enzymes involved in prostaglandin biosynthesis
3. DNA and RNA binding agents